منابع مشابه
Cell Therapy for Refractory Angina: A Reappraisal
Cardiac cell-based therapy has emerged as a novel therapeutic option for patients dealing with untreatable refractory angina (RA). However, after more than a decade of controlled studies, no definitive consensus has been reached regarding clinical efficacy. Although positive results in terms of surrogate endpoints have been suggested by early and phase II clinical studies as well as by meta-ana...
متن کاملRepeat Cell Therapy for Refractory Angina: Déjà vu All Over Again?
B ecause the mortality for ischemic heart disease has improved, an increasing number of patients exhaust their revascularization options and are left with refractory angina. Previous studies suggested that up to 15% of patients undergoing catheterization are suboptimal candidates for further revas-cularization. 4 This number may be growing because a recent analysis from the Duke Databank for Ca...
متن کاملRefractory Angina Pectoris: Focus on Cell Therapy
Although medical and surgical treatments often provide adequate solutions for individuals with coronary artery disease, an increasing need exists to develop treatment modalities for those patients with angina who are unresponsive to medical therapy, have serious coronary atherosclerosis, and are not eligible for percutaneous techniques or bypass surgery, a condition known as refractory angina p...
متن کاملIntramyocardial, autologous CD34+ cell therapy for refractory angina.
RATIONALE A growing number of patients with coronary disease have refractory angina. Preclinical and early-phase clinical data suggest that intramyocardial injection of autologous CD34+ cells can improve myocardial perfusion and function. OBJECTIVE Evaluate the safety and bioactivity of intramyocardial injections of autologous CD34+ cells in patients with refractory angina who have exhausted ...
متن کاملTreatment options for refractory angina pectoris: enhanced external counterpulsation therapy.
Refractory angina pectoris, defined as angina refractory to maximal medical therapy and standard coronary revascularization procedures, remains a significant health problem in the United States and the world. Despite a panoply of recent therapeutic advances, patients with refractory angina pectoris are not adequately treated; therefore, scientists have been investigating new technologies to hel...
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ژورنال
عنوان ژورنال: Circulation: Cardiovascular Interventions
سال: 2015
ISSN: 1941-7640,1941-7632
DOI: 10.1161/circinterventions.115.003049